Islet autoantibodies and residual beta-cell function in children with type 1 diabetes depending on age of manifestation

BACKGROUND : Type 1 diabetes mellitus (T1D) is an autoimmune disorder that leads to pancreatic β-cells destruction and progressive decrease of insulin secretion. Specific islet autoantibodies (AAbs) are the main diagnostic marker T1D. Residual β-cell function, as measured by C-peptide, has repeatedly been demonstrated be clinically important. AIM: To study frequency levels residual C-peptide secretion persistence AAbs in children with T1D different duration age manifestation disease. MATERIALS AND METHODS The ZnT8 (zinc transporter 8), IA-2 (Insulinoma Antigen 2), GAD (Glutamate Decarboxylase), IAA (insulin autoantibodies) were measured. Patients divided into 3 groups depending on (1st — <1 year, 2nd from 5 years, 3rd >5 years) (A prepubertal B puberty). RESULTS: median was 1.8 [0,8;3,9], 76.3% out 1333 patients seropositive, 40% had C-peptide. With disease there a AAbs+: 1st group 74%, 69%, 48%. In all groups, percentage positive one or more significantly higher at puberty. GADA ZnT8A common first year IA-2A observed same adolescents. age. An undetectable level (p<0.05): 1А 13% 1B 5%, 2А 51% 2B 14%, 3А 82% 3B 50%, reference range adolescents (p<0,05): 6% 44%, 2% 2b 25%, 11%. CONCLUSION: AAbs+ relatively about half them seropositive than years after manifestation. have high specificity for new-onset depends